15-Oxygenated 14-Chloro-5β, 14β-cardenolides

New Bufadienolides Isolated from the Roots of Kalanchoe daigremontiana (Crassulaceae).

An aqueous extract from the roots of Kalanchoe daigremontiana turned out to be a rich source of bufadienolides. The existing literature data relate mainly to the aerial parts of Kalanchoe but there is no information about the metabolic profile of the roots, which are also used in traditional medicine. Our investigation concerning the roots of K. daigremontiana led to the isolation and character...

Inhibition of sterol biosynthesis in animal cells by 14 alpha-alkyl-substituted 15-oxygenated sterols.

Reported herein are the results of investigations of the effects of a number of 14 alpha-alkyl-substituted 15-oxygenated sterols, prepared by chemical synthesis, on sterol biosynthesis and the levels of 3-hydroxy-3-methylglutaryl CoA reductase activity in L cells and in primary cultures of fetal mouse liver cells grown in serum-free media. Several of the compounds, most notably 14 alpha-ethyl-5...

12β,14-Dihy­droxy-3-oxo-5β,20(22)-cardenolide monohydrate

The title compound, digoxigenone, C(23)H(30)O(5)·H(2)O, was biotransformed from digoxigenin. In the crystal, inter-molecular O-H⋯O hydrogen bonds contribute to the formation of a three-dimensional supra-molecular structure. The title compound has three fused six-membered rings (A,B,C) and two non-fused five-membered rings (D,E). As in other structures, compound nucleus has a cis-trans-cis confo...

Schedule , Cont . 14 : 00 - - 14 : 15

Ultra - violet absorption cross sections of isotopically substituted nitrous oxide species : 14 N 14 NO , 15 N 14 NO , 14 N 15 NO and 15 N 15 NO

The isotopically substituted nitrous oxide species 14N14NO, 15N14NO, 14N15NO and 15N15NO were investigated by ultra-violet (UV) absorption spectroscopy. High precision cross sections were obtained for the wavelength range 181 to 218 nm at temperatures of 233 and 283 K. These data are used to calculate photolytic isotopic fractionation constants as a function of wavelength. The fractionation con...